Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Genegroup1	Genegroup2	6.05e-01	5.63e-01	1.63e-01	7.84e-01
Genegroup2	Genegroup1	8.12e-01	8.40e-01	9.68e-01	5.45e-01



Evaluating how well Genegroup1 genes are linked to Genegroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.54	-0.35	-0.18	-1.10	0.08
Genegroup2	Genegroup1	0.38	-0.61	-0.41	-0.90	-0.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.00	-0.42	-0.33	-0.54	-0.14
Genegroup2	Genegroup1	0.00	-0.24	-0.20	-0.30	-0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Genegroup1	5	5	
Genegroup2	4	3	Parkin