Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
reactome Exclusive	Somatic GS	3.16e-03	2.47e-01	9.55e-07	6.70e-14
Somatic GS Exclusive	reactome	1.29e-02	2.05e-01	3.77e-15	6.22e-10
reactome Exclusive	Somatic GS Exclusive	7.32e-02	6.81e-01	3.25e-05	1.57e-11
Somatic GS Exclusive	reactome Exclusive	1.19e-02	1.73e-01	1.97e-13	6.94e-09
reactome Exclusive	Overlap	5.46e-04	3.22e-02	2.19e-05	2.88e-05
Somatic GS Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.75e-05
Overlap	Exclusives	1.16e-21	1.04e-16	2.44e-52	1.39e-32



Evaluating how well reactome genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
reactome Exclusive	Somatic GS	0.86	-1.60	2.13	1.34	8.83
Somatic GS Exclusive	reactome	0.69	-0.36	2.49	1.69	8.86
reactome Exclusive	Somatic GS Exclusive	0.84	-2.29	1.23	1.15	7.37
Somatic GS Exclusive	reactome Exclusive	0.68	-0.24	2.01	1.50	6.66
reactome Exclusive	Overlap	0.99	1.29	2.15	1.94	3.71
Somatic GS Exclusive	Overlap	0.99	1.21	2.67	2.50	4.28
Overlap	Exclusives	0.81	2.21	11.02	3.14	14.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
reactome Exclusive	Somatic GS	0.01	-1.94	3.36	1.53	14.47
Somatic GS Exclusive	reactome	0.02	-0.88	2.47	3.56	9.46
reactome Exclusive	Somatic GS Exclusive	0.01	-1.78	0.64	0.59	15.01
Somatic GS Exclusive	reactome Exclusive	0.01	-0.80	1.03	1.81	8.42
reactome Exclusive	Overlap	0.02	-0.88	11.34	4.66	40.68
Somatic GS Exclusive	Overlap	0.02	-0.41	41.40	23.57	26.14
Overlap	Exclusives	0.08	11.04	54.34	22.28	114.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
reactome Exclusive	132	132	
Somatic GS Exclusive	35	35	
Overlap	5	5