Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING Exclusive	Somatic GS	4.78e-02	8.43e-01	7.26e-02	2.18e-09
Somatic GS Exclusive	STRING	1.32e-06	2.99e-02	1.55e-20	1.93e-02
STRING Exclusive	Somatic GS Exclusive	7.21e-02	5.52e-01	8.89e-02	6.37e-09
Somatic GS Exclusive	STRING Exclusive	3.21e-07	2.08e-02	3.43e-20	2.89e-02
STRING Exclusive	Overlap	2.93e-01	9.78e-01	4.52e-01	2.00e-02
Somatic GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	8.46e-04	9.31e-02	1.59e-73	2.14e-03



Evaluating how well STRING genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING Exclusive	Somatic GS	0.81	-1.17	-0.42	-1.60	7.29
Somatic GS Exclusive	STRING	0.53	-0.09	2.16	1.41	2.26
STRING Exclusive	Somatic GS Exclusive	0.80	-1.22	-0.36	-1.47	6.36
Somatic GS Exclusive	STRING Exclusive	0.53	-0.26	1.95	1.44	1.99
STRING Exclusive	Overlap	0.97	0.96	0.68	0.85	2.16
Somatic GS Exclusive	Overlap	0.99	1.18	2.45	1.80	2.46
Overlap	Exclusives	0.55	-0.07	1.28	0.92	2.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING Exclusive	Somatic GS	0.02	-1.25	-0.30	-0.84	5.84
Somatic GS Exclusive	STRING	0.02	0.63	2.35	1.11	1.44
STRING Exclusive	Somatic GS Exclusive	0.02	-1.21	0.31	-0.57	28.69
Somatic GS Exclusive	STRING Exclusive	0.02	0.42	1.78	0.93	0.84
STRING Exclusive	Overlap	0.00	-0.02	-0.35	-0.21	0.77
Somatic GS Exclusive	Overlap	0.01	0.09	38.55	24.97	8.79
Overlap	Exclusives	0.03	0.35	3.32	1.44	4.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING Exclusive	394	393	PAK6
Somatic GS Exclusive	38	38	
Overlap	2	2