Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING Exclusive	Familial GS	7.28e-04	5.44e-03	1.38e-02	1.72e-18
Familial GS Exclusive	STRING	4.31e-14	3.74e-02	9.70e-33	4.21e-02
STRING Exclusive	Familial GS Exclusive	3.73e-03	1.56e-02	2.89e-02	4.58e-16
Familial GS Exclusive	STRING Exclusive	2.80e-14	4.49e-02	6.81e-31	4.46e-02
STRING Exclusive	Overlap	1.79e-01	1.11e-01	3.95e-01	2.78e-03
Familial GS Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.86e-04
Overlap	Exclusives	1.12e-07	5.94e-02	1.08e-18	1.62e-02



Evaluating how well STRING genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING Exclusive	Familial GS	0.93	2.35	4.47	1.59	8.38
Familial GS Exclusive	STRING	0.53	-1.93	1.77	1.00	2.20
STRING Exclusive	Familial GS Exclusive	0.94	2.74	4.83	2.02	7.73
Familial GS Exclusive	STRING Exclusive	0.52	-2.10	1.56	0.90	1.49
STRING Exclusive	Overlap	0.90	1.57	2.06	1.14	2.74
Familial GS Exclusive	Overlap	1.00	1.82	3.67	2.27	3.44
Overlap	Exclusives	0.52	-0.26	0.05	0.15	2.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING Exclusive	Familial GS	0.02	-0.88	-1.08	-0.85	3.94
Familial GS Exclusive	STRING	0.03	7.94	14.44	7.30	11.33
STRING Exclusive	Familial GS Exclusive	0.01	-0.95	-1.29	-0.65	28.06
Familial GS Exclusive	STRING Exclusive	0.02	1.12	4.54	1.96	3.03
STRING Exclusive	Overlap	0.00	-0.19	-0.27	-0.27	2.28
Familial GS Exclusive	Overlap	0.39	77.43	1671.43	369.00	252.86
Overlap	Exclusives	0.03	2.79	6.95	3.44	7.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING Exclusive	392	391	PAK6
Familial GS Exclusive	27	27	
Overlap	4	4