Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_67_genes Exclusive	Somatic GS	1.16e-01	1.94e-01	3.58e-04	9.59e-11
Somatic GS Exclusive	top_67_genes	8.09e-02	8.20e-01	7.85e-07	6.38e-03
top_67_genes Exclusive	Somatic GS Exclusive	4.14e-01	1.35e-01	1.18e-03	3.63e-10
Somatic GS Exclusive	top_67_genes Exclusive	6.81e-02	8.11e-01	6.36e-06	2.13e-02
top_67_genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Somatic GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.42e-02
Overlap	Exclusives	6.04e-12	6.45e-10	4.05e-22	1.70e-16



Evaluating how well top_67_genes genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_67_genes Exclusive	Somatic GS	0.82	-0.58	0.68	1.08	6.43
Somatic GS Exclusive	top_67_genes	0.60	-0.42	0.38	0.89	3.18
top_67_genes Exclusive	Somatic GS Exclusive	0.81	-0.76	0.54	0.88	5.76
Somatic GS Exclusive	top_67_genes Exclusive	0.59	-0.52	0.19	0.55	2.67
top_67_genes Exclusive	Overlap	1.00	1.48	1.41	1.64	2.57
Somatic GS Exclusive	Overlap	0.99	1.20	2.56	1.53	2.55
Overlap	Exclusives	0.74	4.34	4.80	2.66	8.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_67_genes Exclusive	Somatic GS	0.01	-0.25	3.71	2.51	18.05
Somatic GS Exclusive	top_67_genes	0.01	-0.51	0.20	2.66	1.63
top_67_genes Exclusive	Somatic GS Exclusive	0.01	-0.73	2.17	1.44	11.90
Somatic GS Exclusive	top_67_genes Exclusive	0.01	-0.72	-0.00	1.29	3.30
top_67_genes Exclusive	Overlap	0.01	13.88	38.16	13.74	58.61
Somatic GS Exclusive	Overlap	0.01	0.52	42.34	17.34	3.75
Overlap	Exclusives	0.02	16.05	19.13	8.56	35.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_67_genes Exclusive	65	65	
Somatic GS Exclusive	38	38	
Overlap	2	2