Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top genes Exclusive	Somatic GS	1.08e-01	1.54e-01	1.84e-04	2.27e-11
Somatic GS Exclusive	Top genes	7.31e-02	7.96e-01	1.65e-06	7.05e-03
Top genes Exclusive	Somatic GS Exclusive	4.43e-01	1.90e-01	3.46e-04	5.89e-10
Somatic GS Exclusive	Top genes Exclusive	7.13e-02	7.44e-01	2.15e-06	3.74e-02
Top genes Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Somatic GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Overlap	Exclusives	1.84e-11	7.17e-10	5.43e-20	1.46e-16



Evaluating how well Top genes genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top genes Exclusive	Somatic GS	0.82	-0.81	0.66	1.25	8.07
Somatic GS Exclusive	Top genes	0.60	-0.31	0.40	0.73	3.00
Top genes Exclusive	Somatic GS Exclusive	0.81	-0.81	0.47	1.05	6.75
Somatic GS Exclusive	Top genes Exclusive	0.59	-0.44	0.36	0.73	2.42
Top genes Exclusive	Overlap	1.00	1.63	1.59	1.67	2.62
Somatic GS Exclusive	Overlap	0.99	1.23	2.60	1.67	2.34
Overlap	Exclusives	0.74	4.27	4.50	2.02	9.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top genes Exclusive	Somatic GS	0.01	-0.42	3.73	2.74	14.46
Somatic GS Exclusive	Top genes	0.01	-0.51	0.30	2.41	4.52
Top genes Exclusive	Somatic GS Exclusive	0.01	-0.80	2.33	1.48	6.18
Somatic GS Exclusive	Top genes Exclusive	0.01	-0.72	-0.02	2.06	0.91
Top genes Exclusive	Overlap	0.01	13.08	39.95	20.94	9.94
Somatic GS Exclusive	Overlap	0.01	0.94	42.33	12.58	5.60
Overlap	Exclusives	0.02	14.78	18.03	6.93	36.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top genes Exclusive	65	65	
Somatic GS Exclusive	38	38	
Overlap	2	2