Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	1.05e-01	6.34e-02	2.65e-01	2.22e-03
GS Exclusive	gene_list	1.33e-01	6.59e-01	3.85e-03	4.87e-01
gene_list Exclusive	GS Exclusive	1.90e-02	6.79e-03	9.52e-02	2.95e-03
GS Exclusive	gene_list Exclusive	7.49e-02	4.01e-01	2.85e-03	4.53e-01
gene_list Exclusive	Overlap	1.57e-01	1.85e-01	1.41e-01	1.25e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.03e-02	2.86e-02	2.94e-02	2.52e-02



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.68	-0.69	-0.90	-0.44	1.95
GS Exclusive	gene_list	0.51	-1.36	-0.87	0.05	0.24
gene_list Exclusive	GS Exclusive	0.66	-1.29	-2.10	-0.92	1.91
GS Exclusive	gene_list Exclusive	0.50	-1.69	-1.25	-0.21	0.05
gene_list Exclusive	Overlap	0.94	1.53	1.79	1.62	1.61
GS Exclusive	Overlap	1.00	2.36	2.03	2.26	1.99
Overlap	Exclusives	0.56	0.19	0.46	0.18	1.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	-0.69	-1.05	-0.55	0.45
GS Exclusive	gene_list	0.00	0.47	0.82	1.42	1.17
gene_list Exclusive	GS Exclusive	0.00	-0.85	-1.60	-0.84	0.09
GS Exclusive	gene_list Exclusive	0.00	-1.22	-0.76	-0.56	-0.54
gene_list Exclusive	Overlap	0.00	0.40	0.10	0.45	0.46
GS Exclusive	Overlap	0.04	81.60	111.91	109.81	72.27
Overlap	Exclusives	0.01	2.46	7.82	5.71	15.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	49	48	TMEM105
GS Exclusive	11	11	
Overlap	1	1