Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	3.81e-01	7.03e-01	8.52e-01	1.70e-03
GS Exclusive	gene_list	3.45e-01	8.04e-01	1.17e-03	8.55e-01
gene_list Exclusive	GS Exclusive	6.95e-01	8.21e-01	8.16e-01	2.52e-03
GS Exclusive	gene_list Exclusive	3.69e-01	8.39e-01	4.29e-03	8.18e-01
gene_list Exclusive	Overlap	2.52e-01	1.66e-01	1.66e-01	2.17e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.69e-02	5.12e-02	1.26e-02	2.53e-02



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.75	1.18	1.00	0.59	2.97
GS Exclusive	gene_list	0.52	0.65	0.49	0.22	0.42
gene_list Exclusive	GS Exclusive	0.74	0.50	0.56	0.34	2.51
GS Exclusive	gene_list Exclusive	0.50	0.40	0.02	-0.28	0.11
gene_list Exclusive	Overlap	0.90	1.46	1.57	1.66	1.25
GS Exclusive	Overlap	1.00	2.47	2.04	2.04	1.82
Overlap	Exclusives	0.59	1.18	2.04	1.13	2.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.00	0.42	0.40	0.17	-0.04
GS Exclusive	gene_list	0.00	1.34	3.60	1.47	1.56
gene_list Exclusive	GS Exclusive	0.00	-0.05	0.18	-0.06	0.55
GS Exclusive	gene_list Exclusive	0.00	0.18	0.11	-0.19	-0.14
gene_list Exclusive	Overlap	0.00	0.13	0.63	0.13	-0.08
GS Exclusive	Overlap	0.04	164.61	150.55	67.19	55.25
Overlap	Exclusives	0.01	4.71	11.82	6.11	7.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	49	46	KRTAP7-1;UTS2B;PRAG1
GS Exclusive	11	11	
Overlap	1	1