Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML05	Somatic GS	2.86e-01	1.69e-01	3.84e-01	8.77e-11
Somatic GS	EAML05	8.73e-03	3.86e-01	2.70e-05	5.84e-01



Evaluating how well EAML05 genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML05	Somatic GS	0.82	0.89	1.35	0.92	7.82
Somatic GS	EAML05	0.51	0.80	0.80	0.62	0.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML05	Somatic GS	0.01	1.00	1.47	1.02	2.73
Somatic GS	EAML05	0.01	1.05	0.50	0.36	0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML05	119	118	SEP9
Somatic GS	40	40