Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	GWAS GS	2.60e-01	1.23e-01	1.65e-03	7.90e-02
GWAS GS Exclusive	GeneGroup1	1.86e-02	8.94e-02	5.77e-01	3.07e-03
GeneGroup1 Exclusive	GWAS GS Exclusive	1.58e-01	8.46e-02	2.60e-03	1.07e-01
GWAS GS Exclusive	GeneGroup1 Exclusive	1.14e-02	6.12e-02	6.77e-01	3.11e-03
GeneGroup1 Exclusive	Overlap	4.91e-01	4.00e-01	2.28e-01	5.10e-01
GWAS GS Exclusive	Overlap	1.05e-01	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	3.42e-01	2.15e-01	2.26e-42	4.22e-05



Evaluating how well GeneGroup1 genes are linked to GWAS GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GWAS GS	0.54	-1.38	-2.81	-2.24	2.07
GWAS GS Exclusive	GeneGroup1	0.40	-2.61	-2.66	-2.66	-3.34
GeneGroup1 Exclusive	GWAS GS Exclusive	0.54	-1.89	-2.41	-1.91	1.98
GWAS GS Exclusive	GeneGroup1 Exclusive	0.39	-2.99	-2.63	-2.91	-3.29
GeneGroup1 Exclusive	Overlap	0.73	-0.33	-0.63	-0.91	0.63
GWAS GS Exclusive	Overlap	0.99	0.79	1.90	1.19	1.78
Overlap	Exclusives	0.59	2.10	3.04	1.32	5.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GWAS GS	0.01	-1.27	-2.38	-1.67	0.26
GWAS GS Exclusive	GeneGroup1	0.00	0.18	0.85	-0.08	-0.30
GeneGroup1 Exclusive	GWAS GS Exclusive	0.01	-1.60	-1.81	-1.51	0.19
GWAS GS Exclusive	GeneGroup1 Exclusive	0.00	-0.19	0.20	-0.41	-0.76
GeneGroup1 Exclusive	Overlap	0.00	-0.50	-1.09	-0.69	-0.24
GWAS GS Exclusive	Overlap	0.00	0.69	4.89	6.05	4.80
Overlap	Exclusives	0.02	2.24	3.20	1.14	5.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	79	77	UGT2A1;C11orf97
GWAS GS Exclusive	172	172	
Overlap	1	1