Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML01 Exclusive	Familial GS	4.60e-01	3.71e-01	4.49e-01	5.50e-07
Familial GS Exclusive	EAML01	6.02e-04	8.09e-01	1.52e-07	7.29e-01
EAML01 Exclusive	Familial GS Exclusive	5.75e-01	5.13e-01	4.38e-01	1.45e-06
Familial GS Exclusive	EAML01 Exclusive	5.56e-04	7.41e-01	9.29e-08	8.31e-01
EAML01 Exclusive	Overlap	8.82e-01	8.62e-01	7.79e-01	7.39e-02
Familial GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.49e-04	5.07e-03	4.11e-33	4.77e-04



Evaluating how well EAML01 genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	Familial GS	0.78	-0.44	-1.30	-0.27	6.62
Familial GS Exclusive	EAML01	0.52	0.26	1.28	0.97	0.90
EAML01 Exclusive	Familial GS Exclusive	0.78	-0.36	-1.46	-0.07	4.74
Familial GS Exclusive	EAML01 Exclusive	0.51	0.25	1.24	0.98	0.65
EAML01 Exclusive	Overlap	0.89	-0.13	0.23	-0.32	1.80
Familial GS Exclusive	Overlap	1.00	1.45	2.94	1.76	2.38
Overlap	Exclusives	0.59	4.65	3.30	1.67	4.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	Familial GS	0.01	0.34	-0.61	0.25	10.12
Familial GS Exclusive	EAML01	0.01	0.26	1.21	1.10	0.38
EAML01 Exclusive	Familial GS Exclusive	0.01	0.34	-0.63	0.57	12.34
Familial GS Exclusive	EAML01 Exclusive	0.01	-0.04	0.44	0.33	0.08
EAML01 Exclusive	Overlap	0.00	-0.44	-0.07	-0.43	0.03
Familial GS Exclusive	Overlap	0.02	0.88	100.96	47.96	92.67
Overlap	Exclusives	0.02	15.67	13.28	6.50	12.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML01 Exclusive	136	133	9SEP;SSPO;2MARCH
Familial GS Exclusive	29	29	
Overlap	2	2