Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML01 Exclusive	Germline GS	4.42e-01	2.47e-01	2.10e-01	1.49e-05
Germline GS Exclusive	EAML01	2.47e-05	4.94e-01	1.27e-03	4.36e-01
EAML01 Exclusive	Germline GS Exclusive	5.91e-01	1.58e-01	1.91e-01	5.15e-05
Germline GS Exclusive	EAML01 Exclusive	1.31e-05	3.68e-01	2.29e-03	5.84e-01
EAML01 Exclusive	Overlap	9.01e-01	8.28e-01	8.51e-01	4.62e-02
Germline GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.61e-06	4.91e-05	9.13e-45	9.98e-07



Evaluating how well EAML01 genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	Germline GS	0.68	-0.18	-1.73	-0.39	4.94
Germline GS Exclusive	EAML01	0.51	-0.60	0.39	0.67	0.52
EAML01 Exclusive	Germline GS Exclusive	0.67	-0.02	-1.80	-0.33	4.02
Germline GS Exclusive	EAML01 Exclusive	0.50	-0.89	0.48	0.54	0.07
EAML01 Exclusive	Overlap	0.89	0.04	0.14	-0.09	2.08
Germline GS Exclusive	Overlap	1.00	0.83	2.34	1.68	2.45
Overlap	Exclusives	0.63	4.96	5.72	2.49	5.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	Germline GS	0.01	0.08	-1.52	-0.15	2.80
Germline GS Exclusive	EAML01	0.01	-0.53	0.23	0.36	0.36
EAML01 Exclusive	Germline GS Exclusive	0.01	0.23	-1.57	-0.14	5.35
Germline GS Exclusive	EAML01 Exclusive	0.01	-1.49	-0.21	-0.10	-0.30
EAML01 Exclusive	Overlap	0.00	-0.30	-0.15	-0.36	0.14
Germline GS Exclusive	Overlap	0.02	0.96	88.05	40.78	101.39
Overlap	Exclusives	0.03	30.55	26.33	11.45	17.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML01 Exclusive	136	133	2MARCH;SSPO;9SEP
Germline GS Exclusive	56	56	
Overlap	2	2