Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML01 Exclusive	GWAS GS	3.60e-01	7.00e-01	3.70e-01	9.70e-04
GWAS GS Exclusive	EAML01	1.01e-01	9.77e-01	1.12e-02	9.62e-01
EAML01 Exclusive	GWAS GS Exclusive	3.16e-01	6.68e-01	2.28e-01	3.60e-04
GWAS GS Exclusive	EAML01 Exclusive	1.26e-01	8.34e-01	1.71e-02	7.62e-01
EAML01 Exclusive	Overlap	5.10e-01	7.54e-01	4.35e-01	1.49e-01
GWAS GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.00e-01	2.14e-02	2.23e-65	1.51e-07



Evaluating how well EAML01 genes are linked to GWAS GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	GWAS GS	0.59	-0.49	-0.66	-0.24	4.46
GWAS GS Exclusive	EAML01	0.49	-0.82	-0.24	0.47	-0.02
EAML01 Exclusive	GWAS GS Exclusive	0.59	-0.39	-0.50	-0.08	4.36
GWAS GS Exclusive	EAML01 Exclusive	0.49	-0.63	-0.51	-0.02	-0.51
EAML01 Exclusive	Overlap	0.85	-0.13	-0.14	-0.26	1.68
GWAS GS Exclusive	Overlap	0.99	0.93	1.86	1.07	1.67
Overlap	Exclusives	0.60	2.81	4.01	1.63	6.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML01 Exclusive	GWAS GS	0.01	0.75	-0.29	1.04	5.22
GWAS GS Exclusive	EAML01	0.01	0.56	0.84	0.93	0.51
EAML01 Exclusive	GWAS GS Exclusive	0.01	0.85	-0.15	1.30	5.39
GWAS GS Exclusive	EAML01 Exclusive	0.01	0.32	0.14	0.91	0.19
EAML01 Exclusive	Overlap	0.00	-0.52	-0.66	-0.48	0.68
GWAS GS Exclusive	Overlap	0.00	0.31	4.47	2.59	10.61
Overlap	Exclusives	0.02	2.00	3.01	1.29	6.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML01 Exclusive	137	134	SSPO;2MARCH;9SEP
GWAS GS Exclusive	172	172	
Overlap	1	1