Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI05 Exclusive	Familial GS	7.08e-01	4.38e-03	8.05e-01	1.04e-06
Familial GS Exclusive	EPI05	1.08e-05	1.16e-01	1.64e-06	4.89e-02
EPI05 Exclusive	Familial GS Exclusive	6.76e-01	3.60e-03	8.36e-01	2.23e-06
Familial GS Exclusive	EPI05 Exclusive	1.04e-05	9.19e-02	3.90e-07	4.41e-02
EPI05 Exclusive	Overlap	8.11e-01	3.20e-01	6.52e-01	2.65e-01
Familial GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.55e-03	1.88e-02	5.61e-35	4.13e-03



Evaluating how well EPI05 genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	Familial GS	0.79	0.24	1.75	-0.13	5.78
Familial GS Exclusive	EPI05	0.46	1.15	-2.05	-1.55	-1.91
EPI05 Exclusive	Familial GS Exclusive	0.79	0.18	2.05	-0.23	6.30
Familial GS Exclusive	EPI05 Exclusive	0.46	1.20	-2.19	-1.49	-1.93
EPI05 Exclusive	Overlap	0.89	0.22	0.81	-0.12	1.13
Familial GS Exclusive	Overlap	1.00	0.88	1.65	1.67	1.69
Overlap	Exclusives	0.55	0.99	0.76	0.28	2.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	Familial GS	0.00	-1.01	2.50	-1.04	6.43
Familial GS Exclusive	EPI05	0.01	0.94	-0.24	-0.70	-0.62
EPI05 Exclusive	Familial GS Exclusive	0.00	-1.17	2.46	-0.98	0.79
Familial GS Exclusive	EPI05 Exclusive	0.01	2.62	-0.92	-0.80	-0.88
EPI05 Exclusive	Overlap	0.00	-0.40	0.43	-0.47	0.24
Familial GS Exclusive	Overlap	0.01	-0.07	62.23	22.41	12.91
Overlap	Exclusives	0.02	19.42	7.12	3.70	8.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI05 Exclusive	180	178	UGT2A1;CCDC7
Familial GS Exclusive	30	30	
Overlap	1	1