Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) EPI05 Exclusive Familial GS 7.08e-01 4.38e-03 8.05e-01 1.04e-06 Familial GS Exclusive EPI05 1.08e-05 1.16e-01 1.64e-06 4.89e-02 EPI05 Exclusive Familial GS Exclusive 6.76e-01 3.60e-03 8.36e-01 2.23e-06 Familial GS Exclusive EPI05 Exclusive 1.04e-05 9.19e-02 3.90e-07 4.41e-02 EPI05 Exclusive Overlap 8.11e-01 3.20e-01 6.52e-01 2.65e-01 Familial GS Exclusive Overlap 9.92e-02 9.92e-02 9.92e-02 9.92e-02 Overlap Exclusives 4.55e-03 1.88e-02 5.61e-35 4.13e-03 Evaluating how well EPI05 genes are linked to Familial GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) EPI05 Exclusive Familial GS 0.79 0.24 1.75 -0.13 5.78 Familial GS Exclusive EPI05 0.46 1.15 -2.05 -1.55 -1.91 EPI05 Exclusive Familial GS Exclusive 0.79 0.18 2.05 -0.23 6.30 Familial GS Exclusive EPI05 Exclusive 0.46 1.20 -2.19 -1.49 -1.93 EPI05 Exclusive Overlap 0.89 0.22 0.81 -0.12 1.13 Familial GS Exclusive Overlap 1.00 0.88 1.65 1.67 1.69 Overlap Exclusives 0.55 0.99 0.76 0.28 2.53 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) EPI05 Exclusive Familial GS 0.00 -1.01 2.50 -1.04 6.43 Familial GS Exclusive EPI05 0.01 0.94 -0.24 -0.70 -0.62 EPI05 Exclusive Familial GS Exclusive 0.00 -1.17 2.46 -0.98 0.79 Familial GS Exclusive EPI05 Exclusive 0.01 2.62 -0.92 -0.80 -0.88 EPI05 Exclusive Overlap 0.00 -0.40 0.43 -0.47 0.24 Familial GS Exclusive Overlap 0.01 -0.07 62.23 22.41 12.91 Overlap Exclusives 0.02 19.42 7.12 3.70 8.12 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes EPI05 Exclusive 180 178 UGT2A1;CCDC7 Familial GS Exclusive 30 30 Overlap 1 1