Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI05 Exclusive	Germline GS	4.98e-02	4.46e-02	4.52e-01	1.75e-06
Germline GS Exclusive	EPI05	6.92e-05	1.02e-01	5.96e-02	5.89e-02
EPI05 Exclusive	Germline GS Exclusive	3.29e-02	3.78e-02	3.87e-01	1.29e-06
Germline GS Exclusive	EPI05 Exclusive	7.64e-05	1.37e-01	3.05e-02	4.12e-02
EPI05 Exclusive	Overlap	7.84e-01	9.43e-01	8.14e-01	4.53e-01
Germline GS Exclusive	Overlap	8.14e-01	3.89e-01	9.85e-02	1.99e-01
Overlap	Exclusives	8.76e-05	4.73e-03	1.49e-16	2.78e-04



Evaluating how well EPI05 genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	Germline GS	0.71	0.63	2.06	0.08	5.52
Germline GS Exclusive	EPI05	0.47	0.93	-1.24	-1.37	-1.28
EPI05 Exclusive	Germline GS Exclusive	0.71	0.71	2.08	0.20	5.54
Germline GS Exclusive	EPI05 Exclusive	0.47	0.50	-1.29	-1.19	-1.51
EPI05 Exclusive	Overlap	0.65	-0.53	-0.36	-0.44	0.96
Germline GS Exclusive	Overlap	0.75	-0.90	0.60	0.75	1.56
Overlap	Exclusives	0.57	3.31	1.60	0.88	3.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	Germline GS	0.01	-0.18	2.19	-0.65	1.30
Germline GS Exclusive	EPI05	0.01	2.78	0.36	-0.54	-0.53
EPI05 Exclusive	Germline GS Exclusive	0.01	-0.22	2.22	-0.52	5.04
Germline GS Exclusive	EPI05 Exclusive	0.01	1.79	-0.04	-0.61	-0.66
EPI05 Exclusive	Overlap	0.00	-0.71	-0.60	-0.71	-0.11
Germline GS Exclusive	Overlap	0.00	-0.09	19.48	6.30	0.75
Overlap	Exclusives	0.02	4.78	4.28	1.82	6.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI05 Exclusive	178	176	CCDC7;UGT2A1
Germline GS Exclusive	55	55	
Overlap	3	3