Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI05 Exclusive	GWAS GS	9.64e-04	2.04e-02	1.04e-04	4.24e-02
GWAS GS Exclusive	EPI05	1.16e-03	3.17e-02	2.35e-01	1.90e-02
EPI05 Exclusive	GWAS GS Exclusive	4.44e-04	3.40e-02	8.27e-05	3.58e-02
GWAS GS Exclusive	EPI05 Exclusive	1.14e-03	5.10e-02	2.72e-01	1.90e-02
EPI05 Exclusive	Overlap	7.73e-01	2.92e-01	5.70e-01	1.33e-01
GWAS GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.66e-01	1.09e-01	2.33e-51	2.22e-05



Evaluating how well EPI05 genes are linked to GWAS GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	GWAS GS	0.54	-3.00	-2.75	-2.91	1.56
GWAS GS Exclusive	EPI05	0.45	-1.57	-3.13	-2.40	-2.39
EPI05 Exclusive	GWAS GS Exclusive	0.53	-3.07	-3.01	-3.09	1.67
GWAS GS Exclusive	EPI05 Exclusive	0.45	-1.65	-2.74	-2.53	-2.61
EPI05 Exclusive	Overlap	0.88	-0.17	0.79	-0.24	1.44
GWAS GS Exclusive	Overlap	0.99	0.83	1.71	1.20	1.72
Overlap	Exclusives	0.57	1.75	2.74	0.72	4.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI05 Exclusive	GWAS GS	0.01	-2.87	-2.19	-2.20	0.41
GWAS GS Exclusive	EPI05	0.01	-1.32	-2.80	-1.78	-1.45
EPI05 Exclusive	GWAS GS Exclusive	0.01	-2.30	-2.70	-2.11	0.58
GWAS GS Exclusive	EPI05 Exclusive	0.01	-1.42	-2.59	-1.45	-2.18
EPI05 Exclusive	Overlap	0.00	-0.50	0.43	-0.52	0.53
GWAS GS Exclusive	Overlap	0.00	0.82	4.40	3.74	10.20
Overlap	Exclusives	0.02	2.11	2.21	0.80	4.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI05 Exclusive	180	178	UGT2A1;CCDC7
GWAS GS Exclusive	172	172	
Overlap	1	1