Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01	Familial GS	1.31e-01	1.44e-01	3.80e-03	6.56e-03
Familial GS	EPI01	4.54e-05	1.62e-01	9.05e-04	3.01e-03



Evaluating how well EPI01 genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01	Familial GS	0.66	-1.34	-2.36	-1.84	2.95
Familial GS	EPI01	0.41	-0.62	-2.41	-2.31	-3.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01	Familial GS	0.00	-1.11	-1.51	-1.14	1.49
Familial GS	EPI01	0.00	-0.05	-1.68	-1.06	-2.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01	115	114	DKK 3.00
Familial GS	31	31