Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01	Germline GS	4.67e-03	2.03e-01	5.84e-04	9.80e-04
Germline GS	EPI01	5.43e-04	6.02e-01	7.84e-02	7.43e-02



Evaluating how well EPI01 genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01	Germline GS	0.61	-1.38	-1.91	-1.31	3.47
Germline GS	EPI01	0.45	-0.06	-0.93	-0.90	-2.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01	Germline GS	0.00	-1.15	-1.76	-1.08	0.18
Germline GS	EPI01	0.01	-0.28	-0.97	-0.84	-1.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01	115	114	DKK 3.00
Germline GS	58	58