Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01 Exclusive	GWAS GS	7.89e-01	5.49e-01	2.00e-02	5.07e-03
GWAS GS Exclusive	EPI01	7.06e-03	2.47e-01	2.37e-01	6.34e-03
EPI01 Exclusive	GWAS GS Exclusive	7.72e-01	6.28e-01	1.43e-02	3.89e-03
GWAS GS Exclusive	EPI01 Exclusive	6.02e-03	2.17e-01	2.91e-01	6.72e-03
EPI01 Exclusive	Overlap	4.00e-01	2.40e-01	1.85e-01	4.17e-01
GWAS GS Exclusive	Overlap	5.10e-01	2.52e-01	1.33e-01	3.06e-01
Overlap	Exclusives	8.98e-04	3.29e-01	6.15e-15	7.51e-04



Evaluating how well EPI01 genes are linked to GWAS GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01 Exclusive	GWAS GS	0.57	-0.48	-0.68	-1.18	3.32
GWAS GS Exclusive	EPI01	0.43	-1.06	-1.28	-1.50	-3.25
EPI01 Exclusive	GWAS GS Exclusive	0.57	-0.55	-0.45	-1.09	3.97
GWAS GS Exclusive	EPI01 Exclusive	0.43	-1.10	-1.49	-1.60	-2.62
EPI01 Exclusive	Overlap	0.31	-0.85	-1.08	-1.38	-0.71
GWAS GS Exclusive	Overlap	0.81	0.50	0.93	0.99	0.98
Overlap	Exclusives	0.57	1.80	2.27	1.48	3.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01 Exclusive	GWAS GS	0.01	-0.83	-1.28	-1.42	1.18
GWAS GS Exclusive	EPI01	0.01	-0.33	-0.46	-0.54	-0.97
EPI01 Exclusive	GWAS GS Exclusive	0.01	-0.88	-1.12	-1.25	1.32
GWAS GS Exclusive	EPI01 Exclusive	0.01	-0.21	-0.40	-0.73	-1.32
EPI01 Exclusive	Overlap	0.00	-0.48	-0.55	-0.29	-0.23
GWAS GS Exclusive	Overlap	0.00	-0.17	0.69	0.02	-0.08
Overlap	Exclusives	0.02	1.32	1.15	0.83	3.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01 Exclusive	114	113	DKK 3.00
GWAS GS Exclusive	172	172	
Overlap	1	1