Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01 Exclusive	Germline GS	3.04e-02	3.36e-02	5.74e-02	6.73e-07
Germline GS Exclusive	EPI01	9.54e-02	1.09e-01	5.26e-04	1.25e-02
EPI01 Exclusive	Germline GS Exclusive	9.46e-02	3.09e-02	2.99e-02	2.50e-06
Germline GS Exclusive	EPI01 Exclusive	6.46e-02	1.86e-01	1.30e-03	2.21e-02
EPI01 Exclusive	Overlap	1.63e-01	9.85e-02	1.30e-01	6.02e-03
Germline GS Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.60e-03
Overlap	Exclusives	9.93e-07	1.13e-05	4.92e-36	5.90e-11



Evaluating how well EPI01 genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01 Exclusive	Germline GS	0.73	1.07	1.85	0.50	5.22
Germline GS Exclusive	EPI01	0.57	2.32	1.78	1.13	2.87
EPI01 Exclusive	Germline GS Exclusive	0.72	0.72	1.93	0.75	5.38
Germline GS Exclusive	EPI01 Exclusive	0.56	1.94	1.38	1.10	2.19
EPI01 Exclusive	Overlap	0.94	0.86	1.64	0.92	2.49
Germline GS Exclusive	Overlap	1.00	1.05	2.26	1.87	3.08
Overlap	Exclusives	0.67	3.38	6.26	2.23	8.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01 Exclusive	Germline GS	0.01	0.13	2.19	0.25	2.00
Germline GS Exclusive	EPI01	0.01	3.80	2.88	1.69	3.34
EPI01 Exclusive	Germline GS Exclusive	0.01	0.11	1.80	0.59	3.45
Germline GS Exclusive	EPI01 Exclusive	0.01	2.38	1.43	0.52	1.36
EPI01 Exclusive	Overlap	0.00	0.12	1.50	0.25	2.84
Germline GS Exclusive	Overlap	0.02	1.96	46.77	47.89	8.88
Overlap	Exclusives	0.03	13.60	22.79	10.01	18.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01 Exclusive	127	126	SSPO
Germline GS Exclusive	55	55	
Overlap	3	3