Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI001 Exclusive	Familial GS	6.07e-01	2.64e-01	8.57e-02	4.96e-08
Familial GS Exclusive	EPI001	1.48e-04	9.62e-01	5.53e-08	1.55e-02
EPI001 Exclusive	Familial GS Exclusive	3.15e-01	8.43e-01	5.40e-01	7.12e-07
Familial GS Exclusive	EPI001 Exclusive	1.04e-04	9.24e-01	6.57e-07	7.40e-02
EPI001 Exclusive	Overlap	9.50e-02	1.45e-02	4.95e-03	9.64e-04
Familial GS Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.95e-04
Overlap	Exclusives	1.41e-05	1.49e-03	4.23e-29	3.85e-08



Evaluating how well EPI001 genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI001 Exclusive	Familial GS	0.82	-0.54	0.89	0.21	6.50
Familial GS Exclusive	EPI001	0.57	0.83	-0.09	0.59	3.76
EPI001 Exclusive	Familial GS Exclusive	0.80	-0.84	0.37	-0.10	5.66
Familial GS Exclusive	EPI001 Exclusive	0.55	0.88	-0.55	0.21	2.43
EPI001 Exclusive	Overlap	0.94	0.41	2.10	0.74	2.89
Familial GS Exclusive	Overlap	1.00	1.59	3.58	1.99	3.10
Overlap	Exclusives	0.65	2.68	3.49	1.21	7.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI001 Exclusive	Familial GS	0.01	-1.34	0.54	-0.54	1.23
Familial GS Exclusive	EPI001	0.01	1.02	2.21	2.12	5.82
EPI001 Exclusive	Familial GS Exclusive	0.00	-1.21	-0.33	-0.83	0.76
Familial GS Exclusive	EPI001 Exclusive	0.01	0.70	-0.53	0.11	0.38
EPI001 Exclusive	Overlap	0.00	-0.39	2.34	-0.04	1.69
Familial GS Exclusive	Overlap	0.06	1.64	145.71	64.35	99.16
Overlap	Exclusives	0.02	7.48	11.66	6.17	12.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI001 Exclusive	148	148	
Familial GS Exclusive	27	27	
Overlap	4	4