Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML001 Exclusive	Somatic GS	5.20e-01	7.44e-02	8.91e-01	2.87e-07
Somatic GS Exclusive	EAML001	6.98e-02	7.57e-01	2.38e-03	9.38e-01
EAML001 Exclusive	Somatic GS Exclusive	5.31e-01	1.71e-01	8.38e-01	8.80e-07
Somatic GS Exclusive	EAML001 Exclusive	5.73e-02	6.28e-01	3.07e-03	7.60e-01
EAML001 Exclusive	Overlap	7.34e-01	3.35e-01	7.93e-01	1.49e-01
Somatic GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.03e-04	4.58e-03	9.08e-34	9.61e-06



Evaluating how well EAML001 genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Somatic GS	0.75	-1.30	-3.33	-0.69	5.42
Somatic GS Exclusive	EAML001	0.50	-0.55	-0.90	-0.76	0.23
EAML001 Exclusive	Somatic GS Exclusive	0.75	-1.51	-2.78	-0.82	5.30
Somatic GS Exclusive	EAML001 Exclusive	0.50	-0.79	-0.93	-0.82	-0.11
EAML001 Exclusive	Overlap	0.94	0.21	0.76	0.25	1.42
Somatic GS Exclusive	Overlap	1.00	0.53	2.23	1.37	1.72
Overlap	Exclusives	0.61	1.35	1.16	0.83	4.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Somatic GS	0.01	-1.07	-1.39	-0.65	4.39
Somatic GS Exclusive	EAML001	0.01	-0.84	-0.74	-0.58	-0.19
EAML001 Exclusive	Somatic GS Exclusive	0.01	-1.08	-1.05	-0.64	4.11
Somatic GS Exclusive	EAML001 Exclusive	0.01	-1.41	-1.10	-1.05	-0.55
EAML001 Exclusive	Overlap	0.00	-0.46	0.39	-0.41	-0.00
Somatic GS Exclusive	Overlap	0.01	-0.17	64.91	7.32	15.54
Overlap	Exclusives	0.01	4.49	4.06	1.43	8.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML001 Exclusive	122	119	SERPINA3;SEP9;RFX1
Somatic GS Exclusive	39	39	
Overlap	1	1