Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML001 Exclusive	Familial GS	5.53e-02	8.69e-03	6.40e-02	2.74e-04
Familial GS Exclusive	EAML001	5.43e-03	4.87e-01	3.44e-07	3.20e-01
EAML001 Exclusive	Familial GS Exclusive	3.32e-02	1.46e-02	2.52e-02	1.97e-03
Familial GS Exclusive	EAML001 Exclusive	3.61e-03	4.20e-01	2.25e-07	3.25e-01
EAML001 Exclusive	Overlap	4.89e-01	6.60e-01	3.94e-01	3.53e-02
Familial GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	5.69e-05	7.62e-04	2.39e-27	1.85e-05



Evaluating how well EAML001 genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Familial GS	0.69	-1.67	-4.57	-1.46	3.88
Familial GS Exclusive	EAML001	0.51	1.41	-0.42	-0.60	0.50
EAML001 Exclusive	Familial GS Exclusive	0.68	-1.70	-4.65	-1.82	2.86
Familial GS Exclusive	EAML001 Exclusive	0.50	1.08	-0.42	-0.30	0.14
EAML001 Exclusive	Overlap	0.92	0.35	0.42	0.41	1.91
Familial GS Exclusive	Overlap	1.00	1.10	3.13	2.04	2.34
Overlap	Exclusives	0.60	2.04	1.28	1.02	4.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Familial GS	0.00	-1.09	-2.57	-0.92	3.83
Familial GS Exclusive	EAML001	0.01	-0.14	-0.28	-0.68	-0.06
EAML001 Exclusive	Familial GS Exclusive	0.00	-1.17	-2.49	-1.19	1.34
Familial GS Exclusive	EAML001 Exclusive	0.01	-0.27	-0.63	-1.13	-1.00
EAML001 Exclusive	Overlap	0.00	-0.35	0.10	-0.27	-0.02
Familial GS Exclusive	Overlap	0.02	1.79	110.43	38.67	54.62
Overlap	Exclusives	0.02	13.44	13.78	6.36	13.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML001 Exclusive	121	118	SERPINA3;SEP9;RFX1
Familial GS Exclusive	29	29	
Overlap	2	2