Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML001 Exclusive	Germline GS	1.82e-01	6.34e-02	3.50e-01	9.09e-03
Germline GS Exclusive	EAML001	2.38e-03	8.45e-01	3.01e-02	4.11e-01
EAML001 Exclusive	Germline GS Exclusive	1.10e-01	2.70e-02	1.70e-01	1.22e-02
Germline GS Exclusive	EAML001 Exclusive	2.34e-03	7.05e-01	2.55e-02	5.61e-01
EAML001 Exclusive	Overlap	5.79e-01	5.53e-01	4.17e-01	2.55e-02
Germline GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.31e-07	1.65e-05	5.10e-36	4.28e-08



Evaluating how well EAML001 genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Germline GS	0.62	-1.13	-2.55	-0.94	3.49
Germline GS Exclusive	EAML001	0.51	0.10	-0.30	-0.55	0.37
EAML001 Exclusive	Germline GS Exclusive	0.61	-1.20	-2.41	-1.11	3.41
Germline GS Exclusive	EAML001 Exclusive	0.50	0.10	-0.58	-0.67	-0.05
EAML001 Exclusive	Overlap	0.92	0.24	0.35	0.51	2.14
Germline GS Exclusive	Overlap	1.00	1.02	2.34	1.55	2.67
Overlap	Exclusives	0.63	5.54	2.70	1.76	6.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML001 Exclusive	Germline GS	0.00	-1.11	-2.11	-0.99	1.19
Germline GS Exclusive	EAML001	0.01	-0.18	-0.23	-0.53	-0.02
EAML001 Exclusive	Germline GS Exclusive	0.00	-1.09	-2.30	-0.99	2.01
Germline GS Exclusive	EAML001 Exclusive	0.01	-0.63	-0.53	-0.82	-0.83
EAML001 Exclusive	Overlap	0.00	-0.42	-0.00	-0.19	0.22
Germline GS Exclusive	Overlap	0.02	0.05	88.25	29.65	38.11
Overlap	Exclusives	0.03	34.70	22.25	7.94	26.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML001 Exclusive	121	118	RFX1;SERPINA3;SEP9
Germline GS Exclusive	56	56	
Overlap	2	2