Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01Max	Somatic GS	9.04e-02	5.08e-03	3.33e-01	1.15e-12
Somatic GS	EPI01Max	2.60e-01	9.03e-01	5.68e-05	7.06e-01



Evaluating how well EPI01Max genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max	Somatic GS	0.84	1.29	3.59	0.92	7.06
Somatic GS	EPI01Max	0.49	1.68	0.38	0.11	-0.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max	Somatic GS	0.01	-0.28	4.25	-0.67	12.05
Somatic GS	EPI01Max	0.01	1.99	1.38	1.77	2.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01Max	153	151	SSPO;CT45A3
Somatic GS	40	40