Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01Max Exclusive	Familial GS	2.75e-01	4.51e-01	2.29e-01	1.91e-04
Familial GS Exclusive	EPI01Max	8.95e-07	3.71e-01	1.38e-07	3.21e-01
EPI01Max Exclusive	Familial GS Exclusive	3.30e-01	4.18e-01	2.15e-01	8.50e-04
Familial GS Exclusive	EPI01Max Exclusive	1.10e-06	3.41e-01	2.18e-08	2.16e-01
EPI01Max Exclusive	Overlap	6.60e-01	7.01e-01	9.27e-01	9.05e-02
Familial GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	3.61e-03	1.24e-02	1.79e-20	2.88e-04



Evaluating how well EPI01Max genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max Exclusive	Familial GS	0.71	-1.43	-3.22	-1.43	3.82
Familial GS Exclusive	EPI01Max	0.48	-0.14	-0.83	-0.82	-0.93
EPI01Max Exclusive	Familial GS Exclusive	0.70	-1.67	-2.84	-1.57	3.48
Familial GS Exclusive	EPI01Max Exclusive	0.47	-0.08	-0.97	-0.64	-1.14
EPI01Max Exclusive	Overlap	0.84	0.45	0.67	0.25	1.61
Familial GS Exclusive	Overlap	1.00	1.41	2.36	2.27	2.16
Overlap	Exclusives	0.58	1.75	2.84	0.98	3.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max Exclusive	Familial GS	0.00	-1.11	-2.33	-1.23	3.84
Familial GS Exclusive	EPI01Max	0.01	0.47	-0.16	-0.40	-0.35
EPI01Max Exclusive	Familial GS Exclusive	0.00	-1.40	-2.27	-1.14	0.30
Familial GS Exclusive	EPI01Max Exclusive	0.01	-0.23	-1.04	-0.83	-0.85
EPI01Max Exclusive	Overlap	0.00	-0.26	-0.19	-0.38	0.44
Familial GS Exclusive	Overlap	0.03	4.42	114.22	142.61	108.82
Overlap	Exclusives	0.02	10.10	14.34	6.93	19.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01Max Exclusive	151	149	CT45A3;SSPO
Familial GS Exclusive	29	29	
Overlap	2	2