Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI01Max Exclusive	Germline GS	8.62e-03	2.46e-02	2.07e-04	7.68e-02
Germline GS Exclusive	EPI01Max	2.71e-04	7.63e-01	1.24e-01	4.42e-01
EPI01Max Exclusive	Germline GS Exclusive	4.93e-03	1.86e-02	1.15e-04	1.04e-01
Germline GS Exclusive	EPI01Max Exclusive	1.96e-04	6.61e-01	1.29e-01	2.78e-01
EPI01Max Exclusive	Overlap	6.06e-01	4.40e-01	9.27e-01	6.52e-02
Germline GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.41e-06	1.02e-05	2.62e-27	1.58e-07



Evaluating how well EPI01Max genes are linked to Germline GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max Exclusive	Germline GS	0.60	-1.43	-3.14	-1.85	2.57
Germline GS Exclusive	EPI01Max	0.47	-0.47	-1.07	-0.87	-1.26
EPI01Max Exclusive	Germline GS Exclusive	0.59	-1.52	-3.10	-1.92	2.63
Germline GS Exclusive	EPI01Max Exclusive	0.47	-0.25	-1.14	-0.74	-1.51
EPI01Max Exclusive	Overlap	0.84	0.51	0.32	0.27	1.80
Germline GS Exclusive	Overlap	1.00	1.60	2.81	2.03	2.29
Overlap	Exclusives	0.62	3.39	5.31	2.01	5.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI01Max Exclusive	Germline GS	0.00	-1.08	-1.57	-1.11	1.22
Germline GS Exclusive	EPI01Max	0.01	0.26	-0.28	-0.44	-0.42
EPI01Max Exclusive	Germline GS Exclusive	0.00	-1.10	-1.54	-0.97	2.29
Germline GS Exclusive	EPI01Max Exclusive	0.01	-0.15	-1.05	-0.75	-0.65
EPI01Max Exclusive	Overlap	0.00	-0.21	-0.52	-0.43	0.50
Germline GS Exclusive	Overlap	0.02	5.69	90.32	51.52	81.94
Overlap	Exclusives	0.04	18.69	29.34	11.05	31.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI01Max Exclusive	151	149	SSPO;CT45A3
Germline GS Exclusive	56	56	
Overlap	2	2