Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_ADSP	GS	5.15e-05	1.69e-06	3.41e-04	1.54e-06
GS	98_ADSP	4.91e-01	4.04e-01	3.05e-05	4.91e-01



Evaluating how well 98_ADSP genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_ADSP	GS	0.85	2.91	4.99	2.46	4.22
GS	98_ADSP	0.50	2.60	0.94	0.94	0.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_ADSP	GS	0.00	8.65	10.30	1.72	3.77
GS	98_ADSP	0.01	4.66	4.39	2.61	1.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_ADSP	98	98	
GS	14	14