Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS	EAML_top10	2.92e-09	1.17e-07	1.92e-09	1.59e-08
EAML_top10	GS	1.16e-10	8.90e-11	6.23e-10	2.56e-10



Evaluating how well GS genes are linked to EAML_top10 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS	EAML_top10	0.98	9.85	6.11	6.12	5.21
EAML_top10	GS	0.98	6.25	7.68	3.37	6.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS	EAML_top10	0.02	39.86	88.54	74.94	45.51
EAML_top10	GS	0.08	270.50	329.22	108.72	10.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS	14	14	
EAML_top10	10	10