Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS	EAML_bottom10	1.23e-05	8.90e-04	2.52e-02	2.56e-08
EAML_bottom10	GS	4.29e-04	4.50e-02	3.96e-12	5.45e-01



Evaluating how well GS genes are linked to EAML_bottom10 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS	EAML_bottom10	0.05	-3.54	-2.46	-1.54	-5.19
EAML_bottom10	GS	0.42	-2.72	-4.03	-3.02	-1.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS	EAML_bottom10	0.00	-0.76	-0.78	-0.12	-1.13
EAML_bottom10	GS	0.00	-1.45	-2.30	-0.87	-0.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS	14	14	
EAML_bottom10	10	10