Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Women_127 Exclusive	GS	4.92e-02	1.18e-01	7.96e-02	1.01e-02
GS Exclusive	Women_127	1.33e-02	7.63e-01	1.66e-05	9.79e-01
Women_127 Exclusive	GS Exclusive	8.02e-02	3.15e-01	1.48e-01	3.96e-02
GS Exclusive	Women_127 Exclusive	8.90e-03	7.15e-01	1.26e-04	9.59e-01
Women_127 Exclusive	Overlap	2.92e-01	9.92e-02	4.91e-01	1.49e-01
GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.57e-03	2.04e-01	2.56e-30	2.14e-01



Evaluating how well Women_127 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Women_127 Exclusive	GS	0.74	0.95	2.00	1.13	3.20
GS Exclusive	Women_127	0.49	-0.09	0.27	0.61	-0.24
Women_127 Exclusive	GS Exclusive	0.73	1.13	1.76	0.82	2.70
GS Exclusive	Women_127 Exclusive	0.49	-0.25	0.35	0.41	-0.41
Women_127 Exclusive	Overlap	0.92	0.88	2922571130265094.00	0.76	1.67
GS Exclusive	Overlap	1.00	1.72	1796314181429203.00	2.24	1.56
Overlap	Exclusives	0.52	251096287175412.00	1.23	0.98	0.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Women_127 Exclusive	GS	0.00	0.56	-0.07	0.94	0.05
GS Exclusive	Women_127	0.01	0.21	0.78	1.34	0.27
Women_127 Exclusive	GS Exclusive	0.00	0.72	-0.20	0.42	0.32
GS Exclusive	Women_127 Exclusive	0.01	0.09	0.53	0.22	-0.01
Women_127 Exclusive	Overlap	0.00	0.25	inf	0.07	1.12
GS Exclusive	Overlap	0.01	22.45	inf	47.69	32.75
Overlap	Exclusives	0.02	4465912554500669.50	15.34	13.25	17.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Women_127 Exclusive	126	124	OR8G2;FIGNL2
GS Exclusive	13	13	
Overlap	1	1