Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_98 Exclusive	GWAS25	3.51e-03	8.42e-04	6.37e-02	1.83e-05
GWAS25 Exclusive	Combined_98	3.74e-01	6.91e-01	1.78e-01	4.75e-01
Combined_98 Exclusive	GWAS25 Exclusive	3.33e-03	7.05e-04	3.16e-02	6.59e-05
GWAS25 Exclusive	Combined_98 Exclusive	3.96e-01	7.04e-01	3.10e-01	3.68e-01
Combined_98 Exclusive	Overlap	7.73e-01	9.92e-02	4.17e-01	1.75e-01
GWAS25 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.16e-03	8.91e-03	1.80e-28	1.59e-02



Evaluating how well Combined_98 genes are linked to GWAS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_98 Exclusive	GWAS25	0.74	1.97	3.76	1.69	4.33
GWAS25 Exclusive	Combined_98	0.50	1.50	0.60	0.65	-0.15
Combined_98 Exclusive	GWAS25 Exclusive	0.73	1.99	3.90	1.75	3.95
GWAS25 Exclusive	Combined_98 Exclusive	0.49	1.27	0.45	0.37	-0.35
Combined_98 Exclusive	Overlap	0.89	0.27	-367148904465568.50	-0.14	1.38
GWAS25 Exclusive	Overlap	1.00	1.42	111424462830387.00	1.82	1.67
Overlap	Exclusives	0.58	inf	3.83	2.04	3.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_98 Exclusive	GWAS25	0.00	0.90	3.78	1.01	0.18
GWAS25 Exclusive	Combined_98	0.01	2.97	0.87	3.11	2.00
Combined_98 Exclusive	GWAS25 Exclusive	0.00	1.44	3.69	0.66	1.15
GWAS25 Exclusive	Combined_98 Exclusive	0.01	1.77	0.27	0.47	0.30
Combined_98 Exclusive	Overlap	0.00	-0.29	-inf	-0.38	-0.06
GWAS25 Exclusive	Overlap	0.02	24.90	32920936630948200.00	59.84	39.48
Overlap	Exclusives	0.01	inf	9.84	5.33	5.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_98 Exclusive	97	97	
GWAS25 Exclusive	24	23	HLA -DRB1
Overlap	1	1