Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Men_157 Exclusive	GWAS25	5.15e-08	7.08e-08	7.59e-06	2.60e-09
GWAS25 Exclusive	Men_157	2.60e-01	9.55e-02	3.01e-02	1.45e-01
Men_157 Exclusive	GWAS25 Exclusive	1.83e-07	5.73e-08	7.43e-06	1.32e-08
GWAS25 Exclusive	Men_157 Exclusive	2.98e-01	1.18e-01	3.72e-02	1.14e-01
Men_157 Exclusive	Overlap	1.12e-01	9.92e-02	3.06e-01	1.05e-01
GWAS25 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.79e-03	1.57e-02	4.98e-38	2.20e-02



Evaluating how well Men_157 genes are linked to GWAS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Men_157 Exclusive	GWAS25	0.86	3.98	6.22	4.15	5.87
GWAS25 Exclusive	Men_157	0.50	2.33	1.27	1.26	-0.11
Men_157 Exclusive	GWAS25 Exclusive	0.86	3.53	5.08	3.79	5.95
GWAS25 Exclusive	Men_157 Exclusive	0.49	2.15	1.28	1.13	-0.36
Men_157 Exclusive	Overlap	0.98	1.24	-33092268875880.00	0.79	1.58
GWAS25 Exclusive	Overlap	1.00	1.23	111424462830387.00	1.67	2.01
Overlap	Exclusives	0.54	inf	3.24	1.55	1.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Men_157 Exclusive	GWAS25	0.01	14.14	25.22	11.79	17.24
GWAS25 Exclusive	Men_157	0.01	10.01	4.34	7.20	3.70
Men_157 Exclusive	GWAS25 Exclusive	0.01	8.93	21.01	9.47	15.21
GWAS25 Exclusive	Men_157 Exclusive	0.01	6.31	1.36	4.42	5.22
Men_157 Exclusive	Overlap	0.00	2.69	-3021878095539834.00	0.56	2.33
GWAS25 Exclusive	Overlap	0.02	18.10	32920936630948200.00	58.68	85.13
Overlap	Exclusives	0.02	981663763955647.00	12.35	5.26	8.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Men_157 Exclusive	156	154	LOC728392;OR8G2
GWAS25 Exclusive	24	23	HLA -DRB1
Overlap	1	1