Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Women_127 Exclusive	GWAS25	2.96e-05	3.74e-05	1.28e-04	2.25e-08
GWAS25 Exclusive	Women_127	2.92e-01	6.22e-02	1.35e-02	1.22e-01
Women_127 Exclusive	GWAS25 Exclusive	5.42e-05	1.21e-05	3.98e-04	1.15e-07
GWAS25 Exclusive	Women_127 Exclusive	2.53e-01	3.40e-02	2.02e-02	2.05e-01
Women_127 Exclusive	Overlap	1.57e-01	9.92e-02	2.52e-01	1.25e-01
GWAS25 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.63e-03	5.79e-03	4.55e-45	1.23e-02



Evaluating how well Women_127 genes are linked to GWAS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Women_127 Exclusive	GWAS25	0.85	3.22	5.00	3.48	5.74
GWAS25 Exclusive	Women_127	0.54	2.60	2.21	2.11	1.50
Women_127 Exclusive	GWAS25 Exclusive	0.85	2.61	5.69	3.73	6.36
GWAS25 Exclusive	Women_127 Exclusive	0.53	2.82	2.61	2.09	1.40
Women_127 Exclusive	Overlap	0.97	1.10	-10779207183468.00	0.78	1.73
GWAS25 Exclusive	Overlap	1.00	1.35	111424462830387.00	1.66	1.85
Overlap	Exclusives	0.56	inf	3.80	2.10	2.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Women_127 Exclusive	GWAS25	0.01	5.45	11.61	6.75	12.47
GWAS25 Exclusive	Women_127	0.01	3.48	1.32	5.80	3.59
Women_127 Exclusive	GWAS25 Exclusive	0.01	2.23	13.22	7.45	6.35
GWAS25 Exclusive	Women_127 Exclusive	0.01	5.50	0.84	2.88	4.65
Women_127 Exclusive	Overlap	0.00	0.53	-159083759417097.00	0.05	2.22
GWAS25 Exclusive	Overlap	0.02	23.35	32920936630948200.00	35.22	49.17
Overlap	Exclusives	0.01	3044490092728909.00	11.84	4.85	5.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Women_127 Exclusive	126	124	FIGNL2;OR8G2
GWAS25 Exclusive	24	23	HLA -DRB1
Overlap	1	1