Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GroupA	GroupB	8.56e-01	4.25e-01	8.63e-01	2.23e-02
GroupB	GroupA	8.72e-01	8.60e-01	7.60e-02	9.17e-01



Evaluating how well GroupA genes are linked to GroupB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.83	0.22	1.14	0.21	2.30
GroupB	GroupA	0.50	-0.10	-0.42	-0.12	-0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GroupA	GroupB	0.00	0.23	1.07	0.15	0.76
GroupB	GroupA	0.00	0.01	-0.21	-0.18	-0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GroupA	5	5	
GroupB	4	4