Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
E1	s2	2.44e-14	6.27e-13	3.02e-14	7.04e-14
s2	E1	1.97e-13	6.19e-13	3.59e-14	4.02e-13



Evaluating how well E1 genes are linked to s2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
E1	s2	1.00	3.99	6.78	3.56	5.86
s2	E1	0.99	3.71	9.50	4.56	6.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
E1	s2	0.41	658.53	786.69	500.20	955.63
s2	E1	0.24	173.43	714.10	348.13	321.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
E1	16	16	
s2	15	15