Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
B1	B2	7.93e-08	4.38e-08	8.13e-08	3.20e-08
B2	B1	9.39e-08	7.44e-08	1.05e-07	3.11e-07



Evaluating how well B1 genes are linked to B2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B1	B2	0.90	4.35	6.84	4.12	5.96
B2	B1	0.85	4.20	5.93	4.42	4.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B1	B2	0.05	59.56	114.92	60.96	90.84
B2	B1	0.04	7.10	41.30	110.36	118.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
B1	17	17	
B2	22	22