Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
rg1	rg2	3.52e-01	4.62e-01	7.95e-01	2.73e-01
rg2	rg1	1.22e-02	7.55e-01	1.34e-03	2.47e-01



Evaluating how well rg1 genes are linked to rg2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rg1	rg2	0.46	0.02	-0.58	-0.27	-0.63
rg2	rg1	0.55	-1.40	-0.75	-1.11	0.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rg1	rg2	0.00	-0.35	-0.54	-0.42	-0.56
rg2	rg1	0.00	-0.46	-0.38	-0.44	-0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
rg1	20	20	
rg2	20	20