Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADNP	ASB16	3.87e-01	7.42e-01	4.41e-01	3.03e-01
ASB16	ADNP	4.18e-01	2.58e-01	9.68e-03	2.27e-01



Evaluating how well ADNP genes are linked to ASB16 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADNP	ASB16	0.38	-0.95	-0.79	-0.61	-1.26
ASB16	ADNP	0.41	-0.92	-1.41	-1.38	-0.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADNP	ASB16	0.00	-0.37	-0.70	-0.37	-0.50
ASB16	ADNP	0.00	-0.67	-0.87	-0.42	-0.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADNP	11	11	
ASB16	11	11