Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADNP Exclusive	ASB16	4.88e-01	7.26e-01	4.40e-01	3.61e-01
ASB16 Exclusive	ADNP	2.33e-01	6.29e-01	3.51e-02	4.06e-01
ADNP Exclusive	ASB16 Exclusive	1.89e-01	7.22e-01	3.34e-01	3.03e-01
ASB16 Exclusive	ADNP Exclusive	7.22e-01	4.29e-01	5.14e-02	4.04e-01
ADNP Exclusive	Overlap	1.18e-01	1.18e-01	1.18e-01	1.05e-01
ASB16 Exclusive	Overlap	3.26e-01	1.18e-01	1.57e-01	2.65e-01
Overlap	Exclusives	8.39e-02	5.83e-01	2.65e-14	8.77e-01



Evaluating how well ADNP genes are linked to ASB16 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADNP Exclusive	ASB16	0.43	-1.01	-0.52	-0.60	-1.09
ASB16 Exclusive	ADNP	0.44	-1.08	-1.67	-1.28	-0.79
ADNP Exclusive	ASB16 Exclusive	0.38	-1.12	-0.89	-0.85	-1.21
ASB16 Exclusive	ADNP Exclusive	0.41	-0.94	-0.90	-1.23	-0.81
ADNP Exclusive	Overlap	0.98	2.29	inf	1.36	1.88
ASB16 Exclusive	Overlap	0.84	-0.86	-inf	-1.34	1.15
Overlap	Exclusives	0.51	1878436993040473.00	2.40	0.49	0.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADNP Exclusive	ASB16	0.00	-0.68	-0.07	-0.41	-0.36
ASB16 Exclusive	ADNP	0.00	-0.96	-1.18	-1.06	-0.62
ADNP Exclusive	ASB16 Exclusive	0.00	-0.70	-0.86	-0.54	-0.52
ASB16 Exclusive	ADNP Exclusive	0.00	-0.85	-0.81	-0.38	-0.85
ADNP Exclusive	Overlap	0.00	5.69	46019884050093080.00	2.67	5.95
ASB16 Exclusive	Overlap	0.00	-0.61	-inf	-0.77	0.15
Overlap	Exclusives	0.00	inf	11.56	0.41	1.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADNP Exclusive	11	11	
ASB16 Exclusive	11	11	
Overlap	1	1