Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	5.72e-03	2.22e-01	2.35e-23	1.38e-21
ctd Exclusive	disc	7.39e-06	1.46e-02	1.70e-22	7.81e-16
disc Exclusive	ctd Exclusive	5.14e-03	2.52e-01	1.86e-22	9.66e-21
ctd Exclusive	disc Exclusive	2.18e-06	2.08e-02	1.23e-21	2.87e-15
disc Exclusive	Overlap	5.53e-01	4.17e-01	1.28e-02	3.69e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.28e-02
Overlap	Exclusives	1.68e-12	1.03e-06	1.08e-41	6.85e-41



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.83	2.89	4.00	3.29	9.98
ctd Exclusive	disc	0.72	-5.32	2.17	2.33	9.70
disc Exclusive	ctd Exclusive	0.83	2.91	3.90	3.51	10.57
ctd Exclusive	disc Exclusive	0.72	-6.51	1.96	2.12	8.50
disc Exclusive	Overlap	0.90	1.43	1.22	1.95	1.99
ctd Exclusive	Overlap	0.99	2.45	2.66	2.14	2.90
Overlap	Exclusives	0.78	3.28	6.99	2.23	15.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.04	2.29	0.72	7.46	42.24
ctd Exclusive	disc	0.03	-1.38	8.34	8.58	17.24
disc Exclusive	ctd Exclusive	0.04	2.09	1.13	9.35	41.81
ctd Exclusive	disc Exclusive	0.03	-2.45	6.03	7.65	16.24
disc Exclusive	Overlap	0.00	-0.41	0.14	0.71	0.59
ctd Exclusive	Overlap	0.05	161.61	427.93	234.21	283.70
Overlap	Exclusives	0.05	12.55	16.05	6.04	35.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	158	158	
ctd Exclusive	101	87	MIR3622B;MIR146A;MIR708;CTR1B;MIR100;MIR124A-3;MIR296;MIR766;MIR505;CTR1C;ATP7;MIR4467;SNAR-I;MIR375
Overlap	2	2