Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	ctd	2.36e-02	5.80e-02	3.05e-24	1.32e-21
ctd Exclusive	ext	2.70e-05	6.90e-05	5.47e-30	8.57e-25
ext Exclusive	ctd Exclusive	1.80e-02	9.29e-02	7.51e-22	2.88e-19
ctd Exclusive	ext Exclusive	8.06e-04	1.13e-04	1.10e-28	4.19e-22
ext Exclusive	Overlap	3.96e-01	9.72e-01	1.98e-04	8.57e-04
ctd Exclusive	Overlap	4.10e-06	4.86e-03	2.62e-06	4.10e-06
Overlap	Exclusives	1.41e-20	5.93e-15	1.73e-59	2.41e-43



Evaluating how well ext genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	ctd	0.82	2.31	3.48	3.23	11.10
ctd Exclusive	ext	0.76	-3.31	4.05	3.19	11.74
ext Exclusive	ctd Exclusive	0.82	2.65	3.00	3.53	10.97
ctd Exclusive	ext Exclusive	0.75	-4.01	3.50	3.51	10.56
ext Exclusive	Overlap	0.92	0.41	1.12	2.05	3.60
ctd Exclusive	Overlap	1.00	2.89	4.14	2.84	4.38
Overlap	Exclusives	0.81	7.95	8.87	3.56	16.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	ctd	0.04	1.30	-1.09	12.19	67.91
ctd Exclusive	ext	0.04	0.56	11.44	12.21	22.62
ext Exclusive	ctd Exclusive	0.03	1.35	-3.03	13.20	40.08
ctd Exclusive	ext Exclusive	0.03	-1.53	5.82	10.19	18.28
ext Exclusive	Overlap	0.01	1.83	2.34	12.37	11.66
ctd Exclusive	Overlap	0.12	23.80	429.01	203.84	230.95
Overlap	Exclusives	0.08	33.11	35.02	22.04	63.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	153	153	
ctd Exclusive	97	83	MIR505;MIR766;MIR296;MIR375;SNAR-I;MIR4467;ATP7;MIR3622B;MIR708;MIR146A;CTR1B;CTR1C;MIR124A-3;MIR100
Overlap	6	6