Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	clinvar	2.20e-01	8.16e-01	2.77e-04	5.73e-05
clinvar Exclusive	ext	8.00e-04	9.74e-02	3.10e-11	7.55e-18
ext Exclusive	clinvar Exclusive	4.35e-01	8.33e-01	8.36e-04	4.30e-04
clinvar Exclusive	ext Exclusive	4.66e-04	7.62e-02	1.81e-10	5.07e-17
ext Exclusive	Overlap	5.53e-01	5.40e-01	1.35e-02	1.91e-02
clinvar Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	9.25e-03	7.48e-05	8.39e-39	2.09e-24



Evaluating how well ext genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	clinvar	0.79	0.86	1.39	1.50	4.77
clinvar Exclusive	ext	0.71	-1.42	2.29	1.42	10.87
ext Exclusive	clinvar Exclusive	0.77	0.91	1.01	1.55	3.82
clinvar Exclusive	ext Exclusive	0.71	-1.67	2.14	1.22	10.15
ext Exclusive	Overlap	0.96	0.58	1.48	1.46	2.22
clinvar Exclusive	Overlap	1.00	1.90	1.92	2.23	2.36
Overlap	Exclusives	0.75	0.34	4.75	1.63	10.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	clinvar	0.01	0.69	-1.38	4.18	16.77
clinvar Exclusive	ext	0.02	0.50	4.25	5.43	14.44
ext Exclusive	clinvar Exclusive	0.01	0.53	3.61	6.90	17.07
clinvar Exclusive	ext Exclusive	0.02	-0.42	2.88	3.73	13.84
ext Exclusive	Overlap	0.00	0.16	-18.82	1.43	7.01
clinvar Exclusive	Overlap	0.05	98.74	348.97	179.30	132.70
Overlap	Exclusives	0.03	4.00	4.46	3.05	16.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	157	157	
clinvar Exclusive	19	19	
Overlap	2	2