Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	dgn	4.00e-01	1.77e-01	1.59e-35	6.27e-21
dgn Exclusive	ext	8.07e-06	5.93e-02	3.76e-25	3.70e-23
ext Exclusive	dgn Exclusive	3.09e-01	2.56e-01	1.61e-31	1.17e-17
dgn Exclusive	ext Exclusive	8.20e-04	3.27e-01	1.39e-19	6.53e-20
ext Exclusive	Overlap	4.64e-01	7.11e-01	2.87e-07	7.76e-06
dgn Exclusive	Overlap	1.11e-08	5.77e-04	3.58e-10	1.63e-08
Overlap	Exclusives	1.39e-23	5.13e-26	3.63e-65	9.69e-61



Evaluating how well ext genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.73	1.16	2.33	3.45	10.57
dgn Exclusive	ext	0.76	-3.32	2.05	2.57	11.68
ext Exclusive	dgn Exclusive	0.72	1.06	2.02	3.43	12.22
dgn Exclusive	ext Exclusive	0.75	-4.37	1.39	1.67	10.94
ext Exclusive	Overlap	0.90	1.25	1.37	2.14	4.51
dgn Exclusive	Overlap	0.98	4.67	4.45	3.78	5.40
Overlap	Exclusives	0.81	3.83	14.59	4.72	22.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	dgn	0.04	0.01	6.00	7.93	32.28
dgn Exclusive	ext	0.04	2.76	6.94	12.49	42.32
ext Exclusive	dgn Exclusive	0.03	-0.11	5.58	6.02	33.09
dgn Exclusive	ext Exclusive	0.02	-2.25	0.67	3.44	23.35
ext Exclusive	Overlap	0.01	1.03	1.15	7.25	19.35
dgn Exclusive	Overlap	0.18	120.01	67.94	174.86	457.51
Overlap	Exclusives	0.09	8.09	39.29	23.16	82.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	144	144	
dgn Exclusive	197	195	PCDH11Y;SERPINA3
Overlap	11	11