Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ext Exclusive	clinvar	3.01e-01	9.76e-01	1.69e-05	8.77e-05
clinvar Exclusive	ext	5.14e-07	4.28e-01	1.43e-09	2.16e-17
ext Exclusive	clinvar Exclusive	6.37e-01	9.84e-01	2.35e-05	1.89e-04
clinvar Exclusive	ext Exclusive	6.94e-07	3.27e-01	1.03e-08	9.19e-17
ext Exclusive	Overlap	1.12e-01	9.92e-02	9.92e-02	9.92e-02
clinvar Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	6.99e-02	3.84e-03	8.42e-58	1.65e-27



Evaluating how well ext genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	clinvar	0.77	0.57	0.25	1.08	3.96
clinvar Exclusive	ext	0.71	-3.16	1.28	0.63	9.13
ext Exclusive	clinvar Exclusive	0.76	0.42	0.24	1.36	3.83
clinvar Exclusive	ext Exclusive	0.70	-2.88	1.48	0.75	8.59
ext Exclusive	Overlap	0.99	0.98	-13612422658164.00	1.05	1.85
clinvar Exclusive	Overlap	1.00	1.85	inf	1.86	1.50
Overlap	Exclusives	0.77	-6159796288688.33	4.83	1.67	12.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ext Exclusive	clinvar	0.02	1.88	-3.98	7.00	33.86
clinvar Exclusive	ext	0.02	-0.35	2.67	4.32	6.96
ext Exclusive	clinvar Exclusive	0.01	1.72	-4.88	6.70	19.08
clinvar Exclusive	ext Exclusive	0.02	-0.81	2.28	3.79	9.71
ext Exclusive	Overlap	0.01	0.83	-2354558002366097.00	3.26	18.40
clinvar Exclusive	Overlap	0.04	104.97	169448680032092768.00	154.44	33.46
Overlap	Exclusives	0.03	545650950581692.00	8.66	2.32	16.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ext Exclusive	154	154	
clinvar Exclusive	20	20	
Overlap	1	1