Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc Exclusive	ctd	2.06e-01	2.05e-01	4.34e-23	8.08e-20
ctd Exclusive	disc	5.97e-05	2.38e-01	6.58e-13	1.86e-09
disc Exclusive	ctd Exclusive	2.24e-01	1.93e-01	5.98e-22	1.09e-18
ctd Exclusive	disc Exclusive	4.27e-05	3.71e-01	1.09e-11	1.67e-09
disc Exclusive	Overlap	5.53e-01	5.40e-01	1.91e-02	4.04e-02
ctd Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.34e-12	7.17e-15	1.04e-63	6.97e-41



Evaluating how well disc genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.81	1.41	2.49	3.07	9.11
ctd Exclusive	disc	0.72	-4.73	0.90	1.53	7.09
disc Exclusive	ctd Exclusive	0.80	1.33	2.57	2.76	10.08
ctd Exclusive	disc Exclusive	0.71	-5.09	0.70	1.31	6.25
disc Exclusive	Overlap	0.94	-0.40	-59319469268338.50	1.14	1.98
ctd Exclusive	Overlap	1.00	2.21	599466416252950.00	1.74	2.37
Overlap	Exclusives	0.83	279248849016754.50	9.34	2.50	15.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc Exclusive	ctd	0.03	0.80	-2.77	10.03	17.52
ctd Exclusive	disc	0.02	1.22	5.17	11.53	27.25
disc Exclusive	ctd Exclusive	0.03	0.82	-2.36	6.48	10.65
ctd Exclusive	disc Exclusive	0.01	-1.41	2.31	5.56	14.42
disc Exclusive	Overlap	0.00	0.12	-3694986890827743.00	3.05	4.57
ctd Exclusive	Overlap	0.20	256.46	444741157407917568.00	236.84	458.27
Overlap	Exclusives	0.07	15230240162821560.00	53.63	13.46	62.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc Exclusive	96	96	
ctd Exclusive	101	87	MIR3622B;MIR4467;ATP7;MIR766;CTR1C;MIR708;MIR505;MIR146A;MIR296;MIR124A-3;MIR375;SNAR-I;MIR100;CTR1B
Overlap	2	2