Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	ctd	8.93e-03	5.32e-03	5.28e-03	2.81e-20
ctd Exclusive	magma_0_01	9.94e-03	2.05e-01	9.45e-09	1.25e-01
magma_0_01 Exclusive	ctd Exclusive	4.72e-03	1.53e-03	1.89e-03	1.64e-19
ctd Exclusive	magma_0_01 Exclusive	1.50e-02	4.86e-01	3.38e-08	4.51e-01
magma_0_01 Exclusive	Overlap	8.12e-01	7.90e-01	9.27e-01	3.41e-02
ctd Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.52e-05
Overlap	Exclusives	4.51e-09	1.77e-08	1.31e-36	7.14e-12



Evaluating how well magma_0_01 genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	ctd	0.81	2.60	4.38	2.46	10.80
ctd Exclusive	magma_0_01	0.54	3.22	1.91	1.81	2.09
magma_0_01 Exclusive	ctd Exclusive	0.81	3.16	5.15	2.80	10.52
ctd Exclusive	magma_0_01 Exclusive	0.53	2.62	1.53	1.50	1.55
magma_0_01 Exclusive	Overlap	0.79	0.30	0.08	0.55	2.35
ctd Exclusive	Overlap	1.00	3.61	3.51	3.74	3.64
Overlap	Exclusives	0.62	5.63	5.53	3.15	8.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	ctd	0.02	1.39	2.97	1.41	20.64
ctd Exclusive	magma_0_01	0.02	22.10	18.74	13.48	15.01
magma_0_01 Exclusive	ctd Exclusive	0.02	1.41	3.01	1.61	18.72
ctd Exclusive	magma_0_01 Exclusive	0.01	4.29	3.56	3.22	3.19
magma_0_01 Exclusive	Overlap	0.00	1.19	0.62	1.90	1.53
ctd Exclusive	Overlap	0.20	392.38	703.98	818.97	252.73
Overlap	Exclusives	0.06	33.98	42.77	26.56	46.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	229	224	C19orf73;DGCR6;IGH;SHANK3;C17orf107
ctd Exclusive	98	84	MIR766;MIR4467;MIR124A-3;MIR100;ATP7;SNAR-I;CTR1B;MIR708;MIR296;MIR3622B;MIR146A;MIR375;MIR505;CTR1C
Overlap	5	5