Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	gwas	1.26e-01	1.10e-01	9.15e-02	1.27e-03
gwas Exclusive	magma_0_01	9.33e-02	4.86e-01	1.91e-02	2.51e-01
magma_0_01 Exclusive	gwas Exclusive	1.45e-01	1.22e-01	1.73e-01	9.52e-03
gwas Exclusive	magma_0_01 Exclusive	7.38e-02	5.91e-01	6.87e-02	3.21e-01
magma_0_01 Exclusive	Overlap	1.68e-01	2.27e-01	2.21e-01	2.13e-02
gwas Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.60e-03
Overlap	Exclusives	1.58e-02	8.97e-03	7.11e-23	1.91e-03



Evaluating how well magma_0_01 genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	gwas	0.71	1.56	1.97	1.16	4.35
gwas Exclusive	magma_0_01	0.52	1.15	1.01	1.25	1.46
magma_0_01 Exclusive	gwas Exclusive	0.68	1.36	1.69	0.92	2.71
gwas Exclusive	magma_0_01 Exclusive	0.52	0.64	0.87	0.78	0.93
magma_0_01 Exclusive	Overlap	0.92	2.11	2.04	1.86	2.34
gwas Exclusive	Overlap	1.00	2.81	2.42	2.90	3.31
Overlap	Exclusives	0.56	2.63	3.18	1.94	2.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	gwas	0.00	2.66	1.70	1.65	4.72
gwas Exclusive	magma_0_01	0.02	3.57	3.74	3.98	4.46
magma_0_01 Exclusive	gwas Exclusive	0.00	1.75	1.46	1.10	0.84
gwas Exclusive	magma_0_01 Exclusive	0.01	0.59	1.64	1.18	1.76
magma_0_01 Exclusive	Overlap	0.00	7.15	3.75	4.62	8.37
gwas Exclusive	Overlap	0.09	292.73	224.86	269.46	81.95
Overlap	Exclusives	0.03	20.43	28.66	14.03	22.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	231	226	C19orf73;IGH;C17orf107;SHANK3;DGCR6
gwas Exclusive	22	21	HLA -DRB1
Overlap	3	3