Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_01 Exclusive	dgn	2.26e-02	1.79e-02	7.54e-03	3.56e-17
dgn Exclusive	magma_0_01	2.06e-02	2.08e-01	2.06e-07	1.05e-01
magma_0_01 Exclusive	dgn Exclusive	3.19e-02	3.09e-02	2.29e-02	1.14e-15
dgn Exclusive	magma_0_01 Exclusive	9.11e-02	3.52e-01	2.04e-05	2.05e-01
magma_0_01 Exclusive	Overlap	4.29e-01	1.37e-01	2.64e-01	1.51e-03
dgn Exclusive	Overlap	7.36e-05	5.90e-04	5.37e-07	1.12e-05
Overlap	Exclusives	9.31e-26	1.53e-28	2.01e-59	3.95e-38



Evaluating how well magma_0_01 genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	dgn	0.70	1.55	2.46	1.81	10.13
dgn Exclusive	magma_0_01	0.54	2.39	1.84	2.26	1.84
magma_0_01 Exclusive	dgn Exclusive	0.69	1.48	2.18	1.40	8.01
dgn Exclusive	magma_0_01 Exclusive	0.52	1.78	1.64	1.56	1.33
magma_0_01 Exclusive	Overlap	0.86	1.78	2.26	2.13	3.26
dgn Exclusive	Overlap	0.97	4.80	4.39	3.28	4.67
Overlap	Exclusives	0.69	6.10	12.87	4.92	13.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_01 Exclusive	dgn	0.03	1.15	3.16	1.59	19.06
dgn Exclusive	magma_0_01	0.03	35.55	30.85	29.60	23.49
magma_0_01 Exclusive	dgn Exclusive	0.02	1.24	2.52	1.10	13.85
dgn Exclusive	magma_0_01 Exclusive	0.01	2.72	2.26	1.48	1.78
magma_0_01 Exclusive	Overlap	0.00	2.37	0.56	3.06	4.81
dgn Exclusive	Overlap	0.50	899.83	794.25	1133.51	1428.96
Overlap	Exclusives	0.13	46.34	104.37	40.61	109.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_01 Exclusive	227	222	C17orf107;SHANK3;DGCR6;C19orf73;IGH
dgn Exclusive	201	199	SERPINA3;PCDH11Y
Overlap	7	7