Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
magma_0_001 Exclusive	ctd	1.11e-06	3.28e-06	1.05e-09	5.42e-22
ctd Exclusive	magma_0_001	3.44e-02	1.07e-02	2.75e-07	1.88e-04
magma_0_001 Exclusive	ctd Exclusive	3.08e-06	3.81e-06	3.87e-11	3.38e-20
ctd Exclusive	magma_0_001 Exclusive	5.57e-02	2.76e-02	1.07e-05	2.53e-03
magma_0_001 Exclusive	Overlap	5.66e-02	7.88e-02	2.22e-02	1.18e-02
ctd Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	3.78e-13	5.03e-22	2.02e-36	4.26e-34



Evaluating how well magma_0_001 genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	ctd	0.82	3.18	7.49	3.11	10.88
ctd Exclusive	magma_0_001	0.68	4.01	2.52	3.07	3.66
magma_0_001 Exclusive	ctd Exclusive	0.81	3.03	6.76	3.45	10.48
ctd Exclusive	magma_0_001 Exclusive	0.65	3.38	2.28	2.40	3.06
magma_0_001 Exclusive	Overlap	0.94	2.22	1.83	2.27	2.52
ctd Exclusive	Overlap	1.00	3.14	2.16	2.68	3.04
Overlap	Exclusives	0.85	6.45	11.11	2.95	11.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
magma_0_001 Exclusive	ctd	0.02	5.26	14.03	5.44	19.44
ctd Exclusive	magma_0_001	0.04	139.17	82.96	90.33	13.02
magma_0_001 Exclusive	ctd Exclusive	0.02	4.35	11.30	6.19	8.57
ctd Exclusive	magma_0_001 Exclusive	0.01	31.59	18.79	27.36	12.47
magma_0_001 Exclusive	Overlap	0.00	8.43	11.12	9.51	5.70
ctd Exclusive	Overlap	0.17	525.67	498.43	259.06	353.59
Overlap	Exclusives	0.07	40.52	87.67	19.89	40.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
magma_0_001 Exclusive	28	28	
ctd Exclusive	100	86	MIR3622B;ATP7;CTR1C;CTR1B;MIR124A-3;MIR505;MIR146A;MIR708;MIR296;MIR4467;MIR100;MIR375;SNAR-I;MIR766
Overlap	3	3